Publications

 

Susa KJ, Seegar TCM, Blacklow SC*, Kruse AC*. A Dynamic Interaction Between CD19 and the Tetraspanin CD81 Controls B Cell Co-Receptor Trafficking. ELife. 2020 Apr 27;9. Pii:e52337. *corresponding author

Adhikari AA, Seegar TCM, Ficarro SB, McCurry MD Ramachandran D, Yao L, Chaudhari SN, Ndousse-Fetter S, Banks AS, Marto JA, Blacklow SC, Devlin AS.  Development of a Braod-Spectrum, Covalent Inhibitor of Gut Bacterial Bile Salt Hydrolases. Nat Chem Biol. 2020 Mar;16(3):318-326.

Seegar TCM*, Blacklow SC*. Domain Integration of ADAM family proteins: Emerging Themes from Structural Studies. Exp Biol Med. 2019 Dec;244(17):1510-1519. *corresponding author

Jarrett S, Seegar TCM, Andrews M, Adelmant G, Marto JA, Aster JC, Blacklow SC. Molecular basis for feedback inhibition of Notch signal by the Notch regulated ankyrin repeat protein NRARP. Sci. Signaling. 2019 Nov 5;12(606), eaay2369.

Rogers JM, Waters CT, Seegar TCM, Jarrett SM, Hallworth AN, Blacklow SC, Bulyk ML. Novel Mechanism of Bispecificity in Forkhead Transcription Factors. Mol Cell. 2019 Apr 18;74(2):245-253.

Seegar TCM, Kingsworth LB, Saha N, Meyer PA, Patra D, Zimmerman B, Janes PW, Rubinstein E, Nikolov DB, Skiniotis G, Kruse AC, Blacklow SCB. Structural Basis for Regulated Proteolysis by the a-Secretase ADAM10. Cell. 2017 Dec14;171(7):1638-1648.

Suliman M, Santosh V, Seegar TCM, Dalton A, Schultz K, Klug C, Barton WA. Directed evolution provides insight into conformational substrate sampling by SrtA. PLOS ONE. 2017 Aug 31;12(8):e0184271.

McMillan BJ, Tibbe C, Drabek A, Seegar TCM, Blacklow SC, Klein T. Structural basis for regulation of ESCRT-III complexes by LGD. Cell Rep. 2017 May30;19(9)1750-1757.

Zimmerman B, Kelly B, McMillan BJ, Seegar TCM, Dror RO, Kruse AC, Blacklow SC. Crystal structure of human tetraspanin CD81 reveals a conserved intramembrane binding cavity. Cell. 2016 Nov3;167(4);1041-1051.

Arnett KL, Seegar TCM, Blacklow SC, (2016) Structural Biology of Notch Signaling. In Targeting Notch in Cancer: From the Fruit Fly to the Clinic (pp.1-33). New York, NY: Springer. (Invited book chapter)

Seegar WS, Yates MA, Doney GE, Jenny PJ, Seegar TC, Perkins C, Giovanni M, (2015). Migrating Tundra Peregrine Falcons accumulate polycyclic aromatic hydrocarbons along Gulf of Mexico following Deepwater Horizon oil spill. Ecotoxicology. 2015 Jul;24(5):1102-11.

Barton WA, Dalton AC, Seegar TCM, Himanen JP, Nikolov DB, (2014) Tie2 and Eph Receptor Tyrosine Kinase Activation and Signaling. In Signaling by Tyrosine Kinases (pp. 287-304). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.

Yu X*, Seegar TCM*, Dalton AC*, Tzvetkova-Robev D, Goldgur Y, Rajashankar KR, Nikolov DB, Barton WA.  Structural basis for angiopoietin-1-mediated signaling initiation.  Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7205-10. (*co-authorship)

Seegar TCM, Barton WA. Imaging protein-protein interactions in vivo.  J Vis Exp. 2010 Oct 10;(44) pii:2149

Seegar TCM, Eller B, Tzvetkova-Robev D, Kolev MV, Henderson SC, Nikolov DB, Barton WA.  Tie1-Tie2 interactions mediate functional differences between angiopoietin ligands. Mol Cell. 2010 Mar 12;37(5):643-55.